| Copyright 2008 Edward Karpman, M.D. All rights reserved. |
Peyronie's Disease
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Peyronie's Disease
presence of excess collagen formations (often called plaque) that affects the erectile bodies of the
penis. The fibrotic lesions reduce penile tissue elasticity and can result in penile
curvature, painful erections, constrictions (hour-glass deformity), loss of length or girth and erectile
dysfunction. The prevalence of PD is reported as high as10% of the male population with a slightly
increasing incidence with older age.
A man's initial response to palpating a hard nodule on the penis can cause a lot of anxiety and
concern about a possible malignancy. Patients can easily be reassured by their physicians that
Peyronie's plaques are benign lesions and are only associated with sexual dysfunction.
Trauma to the penis is one of the most common causes of PD and can result during
regular sexual intercourse when the penis bends or is struck severely, leading to scar tissue
formation or plaques. These plaques can decrease normal tissue elasticity with the resultant
changes in penile appearance. Genetics can predispose patients to PD. The presence of a
family member with PD or other fibrotic tissue disorders such as Dupuytren’s contracture or
plantar fibromatosis is associated with this condition. Medications belonging to certain drug
classes have been reported to cause PD. Beta-blockers, anti-seizure medication (phenytoin)
and certain supplements such as glucosamine / chondroitin or large doses of vitamin C are
associated with PD.
Treatment options for patients with PD are various and depend on the degree of curvature
and sexual disability in the individual patient. Many proven and unproven treatments exist. Your
physician will determine which treatment option is appropriate for you. Treatment options found
to be beneficial include:
+ Penile Prosthesis and Penile Plication/Grafting - in cases of severe Peyronie's Disease
associated with erectile dysfunction, a combination of penile implantation and penile
plication/grafting is required to achieve a good functional and cosmetic result.
Dr Karpman will evaluate the degree of penile deformity and recommend treatment options. You are
encouraged to bring in photographs taken from the best angle demonstrating the degree of the
penile deformity to your appointment. These images will also be used as a baseline to assess the
degree of improvement after therapy.
presence of excess collagen formations (often called plaque) that affects the erectile bodies of the
penis. The fibrotic lesions reduce penile tissue elasticity and can result in penile
curvature, painful erections, constrictions (hour-glass deformity), loss of length or girth and erectile
dysfunction. The prevalence of PD is reported as high as10% of the male population with a slightly
increasing incidence with older age.
A man's initial response to palpating a hard nodule on the penis can cause a lot of anxiety and
concern about a possible malignancy. Patients can easily be reassured by their physicians that
Peyronie's plaques are benign lesions and are only associated with sexual dysfunction.
Trauma to the penis is one of the most common causes of PD and can result during
regular sexual intercourse when the penis bends or is struck severely, leading to scar tissue
formation or plaques. These plaques can decrease normal tissue elasticity with the resultant
changes in penile appearance. Genetics can predispose patients to PD. The presence of a
family member with PD or other fibrotic tissue disorders such as Dupuytren’s contracture or
plantar fibromatosis is associated with this condition. Medications belonging to certain drug
classes have been reported to cause PD. Beta-blockers, anti-seizure medication (phenytoin)
and certain supplements such as glucosamine / chondroitin or large doses of vitamin C are
associated with PD.
Treatment options for patients with PD are various and depend on the degree of curvature
and sexual disability in the individual patient. Many proven and unproven treatments exist. Your
physician will determine which treatment option is appropriate for you. Treatment options found
to be beneficial include:
- Oral Medications
- + Vitamin E
+ Colchicine
+ Pentoxyfilline
- Topical Medications
- + Verapamil Cream
- Plaque injections
- + Verapamil
+ Collagenases
+ Interferon
- Mechanical Traction Devices
- Surgery
- + Penile Plication - the penis is straightened by placing some plication sutures in
the tunic of the corpora cavernosa
- + Penile Grafting - the penis is straightened by excising the plaque and placing a graft
material over the defect
- + Penile Prosthesis and Modeling - the penis is straightened by placing a penile
prosthesis and modelling the penis over the prosthesis. This is the treatment of choice for
men with Peyronie's Disease and concomitant erectile dysfunction (E.D.)
+ Penile Prosthesis and Penile Plication/Grafting - in cases of severe Peyronie's Disease
associated with erectile dysfunction, a combination of penile implantation and penile
plication/grafting is required to achieve a good functional and cosmetic result.
Dr Karpman will evaluate the degree of penile deformity and recommend treatment options. You are
encouraged to bring in photographs taken from the best angle demonstrating the degree of the
penile deformity to your appointment. These images will also be used as a baseline to assess the
degree of improvement after therapy.
Before
After
Before
Before
After
After
